4 edition of Genetic and therapeutic aspects of lipid and purine metabolism found in the catalog.
Genetic and therapeutic aspects of lipid and purine metabolism
|Statement||Günther Wolfram (Ed.).|
|Contributions||Wolfram, G. 1936-, Zöllner, Nepomuk.|
|LC Classifications||QP751 .G46 1989|
|The Physical Object|
|Pagination||xiii, 162 p. :|
|Number of Pages||162|
|LC Control Number||88035576|
Imbalances in hepatic lipid metabolism, leading to accumulation of hepatic triglycerides, insulin resistance, inflammation, and apoptosis, are intimately related to diseases of energy imbalance; these include obesity, diabetes, hyperlipidemia, and atherosclerosis (1,2).Changes in hepatic energy balance are often modulated at the transcriptional level by hormonal signals acting on nuclear. History. Compared to other biomedical fields, lipidology was originally less popular since the constant handling of oils, smears, and greases was unappealing and separation was difficult. The field became more popular following the advent of chromatography which allowed lipids to be isolated and analyzed. The field was further popularized following the cytologic application of the electron. Especially for the liver, imbalanced purine catabolism shed light on the transcriptional activation of xanthine oxidase, which is thought to act in absorbing or possibly triggering oxidative stress. We also applied this system to assess the therapeutic effects of simvastatin administration. The large-scale genome-wide association study, led by UNC's Cynthia M. Bulik, Ph.D., FAED, founding director of the UNC Center of Excellence for Eating Disorders, and Gerome Breen, Ph.D., of King.
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While working in Thannhauser's laboratory he learned to think and act according to the strict laws of natural SCIence.
After returning to Europe he concentrated his scientific work on purines and lipids. Gout and hyperlipoproteinemias from the genetic to the therapeutic aspects remained the dominating topics of his research activities.
Genetic and therapeutic aspects of lipid and purine metabolism. Berlin ; New York: Springer-Verlag, © (OCoLC) Online version: Genetic and therapeutic aspects of lipid and purine metabolism.
Berlin ; New York: Springer-Verlag, © (OCoLC) Named Person: Nepomuk Zöllner; Nepomuk Zöllner: Document Type: Book. While working in Thannhauser's laboratory he learned to think and act according to the strict laws of natural SCIence.
After returning to Europe he concentrated his scientific work on purines and lipids. Gout and hyperlipoproteinemias from the genetic to the therapeutic aspects remained the dominating topics of his research : Gebundenes Buch.
Genetic and Therapeutic Aspects of Lipid and Purine Metabolism (Inglés) Pasta dura – 20 enero por Gunther Wolfram (Editor) Ver todos los formatos y ediciones Ocultar otros formatos y ediciones. Precio de Amazon Nuevo desde Usado desde Pasta dura "Vuelva a intentarlo" — $1, Format: Pasta dura.
Clinical and Therapeutic Aspects. Editors: Rapado, A. (Ed.) Free Preview. Buy this book eB68 Family Study of Lipid and Purine Levels in Gout Patients and Analysis of Mortality.
Pages Book Title Purine Metabolism in Man-III Book Subtitle Clinical and Therapeutic Aspects. The book is well written and easy to read, and its chapter structure and content is logically laid out. The book is a valuable addition to lipidologists and certainly useful for scientists working in fields where lipids are not the core interest but still have importance for solving scientific and/or technical issues., European Journal of Lipid Science and Technology.
Packard C.J., Shepherd J. () Genetics, Drugs and Low Density Lipoprotein Metabolism. In: Wolfram G. (eds) Genetic and Therapeutic Aspects of Lipid and Purine Metabolism. Abstract. Germany has long been in the forefront in highlighting the importance of purines to humans.
It is virtually the centenary of the production of the correct structure for uric acid by the great Emil Fischer and his school () and their demonstration of the relationship with other purine bases. Genetic and Therapeutic Aspects of Lipid and Purine Metabolism Effects of diuretics on uric acid metabolism and excretion.
In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. () Purine Excretion.
In: Wolfram G. (eds) Genetic and Therapeutic Aspects of Lipid and Purine Metabolism. Springer, Berlin. Journals & Books; Help Download full _ Hypoxanthine-guanine phosphoribosyltransferase deficiency: Molecular basis and clinical relevance.
In "Genetic and Therapeutic Aspects of Lipid and Purine Metabolism" (G. Wolfram, Ed.), pp.Springer-Verlag, Berlin. Genetic and Therapeutic Aspects of Lipid and Purine Metabolism, Springer. The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U.
A.) in July and August of Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum.
Genetic and Therapeutic Aspects of Lipid and Purine Metabolism Kather H et al. () Mitigation of alimentary lipemia by postprandial exercise — phenomena and mechanisms.
Metabolism – CrossRef Google Wolfram G. (eds) Genetic and Therapeutic Aspects of Lipid and Purine Metabolism. Springer, Berlin, Heidelberg. https://doi. The general pathways of purine salvage and the enzymes responsible for the different steps as currently known are shown in Figure e of the absence of de novo biosynthesis, most parasites depend mainly on one or two enzymes of the purine salvage pathways to satisfy their purine requirements.
In the following are examples of crucial differences in the salvage metabolism of purines. Growth, Nutrition, and Metabolism of Cells in Culture, Volume 1, summarizes the state of knowledge of the growth, nutrition, and metabolism of various types of cell cultures. The chapters are both detailed and comprehensive enough for the specialist and broad enough to.
Contents include abbreviations and definitions used in the study of lipids, routine analytical methods, fatty acid structure and metabolism, dietary lipids and lipids as energy stores, lipid transport, lipids in cellular structures and the metabolism of structural lipids.
The book provides a most comprehensive treatment of the subject, making Reviews: 1. Biochemical, cell biological and biophysical aspects of the four major groups of lipids in eukaryotic cells, namely glycerophospholipids, sterols, sphingolipids and storage lipids, are reported and discussed.
The experimental systems addressed are mammalian, plant and yeast cells as the most prominent and currently best studied systems in lipid.
Completely revised with 15 new chapters, the book includes coverage of the roles of gut microbiome in obesity and diabetes, macrovascular and microvascular complications, diabetes, metabolic syndrome and kidney disease, aspects of diabetic cardiomyopathy, diabetes, Alzheimer’s and neurodegenerative diseases, roles of SGLT2 inhibitors in the.
The Arabidopsis Book © American Society of Plant Biologists. used genetic analysis to evaluate the function(s) of specif- growth and the relationship of purine metabolism and.
A groundbreaking new approach to understanding, preventing, and treating cancer. Supported by evidence from more than 1, scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as s: These disorders are due to abnormalities in the biosynthesis, interconversion and degradation of the purines—adenine and guanine—and of the pyrimidines—cytosine, thymine and uracil.
All are heterocyclic bases which exist in tri- di- and mono-phosphorylated forms, and as either deoxyribosylated or ribosylated derivatives (deoxyribose and ribose are pentose carbohydrates). Chronic infections with Staphylococcus aureus such as septicemia, osteomyelitis, endocarditis, and biofilm infections are difficult to treat because of persisters.
Despite many efforts in understanding bacterial persistence, the mechanisms of persister formation in S. aureus remain elusive. Here, we performed a genome-wide screen of a transposon mutant library to study the molecular mechanisms. Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease.A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and.
The imbalance of redox status disrupted energy metabolism, amino acid metabolism, purine metabolism, and lipid metabolism. Furthermore, the metabolism disorder resulted in mitochondrial dysfunction and up-regulation of purine metabolism, thus enhancing ROS production and exacerbating CD damage.
CRediT authorship contribution statement. Try before you buy. Get chapter 1 for free. This comprehensive work concisely summarizes Emery & Rimoin's Principles and Practices of Medical Genetics 6th edition into a clinical reference suitable for lab and desk use.
Clinically oriented information is supported by concise descriptions of the principles of genetics, research approaches, and analytics to embrace the evolving population of. Online retailer of specialist medical books, we also stock books focusing on veterinary medicine.
Order your resources today from Wisepress, your medical bookshop. Purine Stones. Xanthine is a type of purine, and xanthinuria is a genetic deficiency of xanthine oxidase, a defect in purine metabolism. Xanthine stones (purine stones) are seen in patients with severe hyperuricemia taking allopurinol, or in those with rare inherited forms of xanthinuria.
2,8-Dihydroxyadenine stones occur in patients with. The meeting probably was the first truly international symposium devoted entirely to basic as well as applied aspects of lipid metabolism as related to the lipid storage disorders.
Participants came from Europe, USA, Israel and Japan, and presented data on research in molecular biology and genetics, enzymology, cell biology as well as medical. Metabolic disease - Metabolic disease - Disorders of carbohydrate metabolism: The metabolism of the carbohydrates galactose, fructose, and glucose is intricately linked through interactions between different enzymatic pathways, and disorders that affect these pathways may have symptoms ranging from mild to severe or even life-threatening.
Inborn errors involving enzymes essential for pyrimidine nucleotide metabolism have provided new insights into their fundamental physiological roles as vital constituents of nucleic acids as well as substrates of lipid and carbohydrate metabolism and in oxidative phosphorylation.
Genetic aberrations. Master the genetics you need to know with the updated 14th Edition of Emery’s Elements of Medical Genetics by Drs.
Peter Turnpenny and Sian Ellard. Review the field’s latest and most important topics with user-friendly coverage designed to help you better understand and apply the basic principles of genetics to clinical situations. Introduction. Decreases in mitochondrial content and function accompanying the development of overweight and obesity represent an underlying mechanism of several metabolic disorders including insulin resistance, dyslipidemia, type II diabetes, hypertension, and cardiovascular disease.1,2 Inan estimated % of the worldwide adult population was overweight and % was obese.3 Current.
Print book: English: 7th edView all editions and formats Summary: With updates in the biochemical underpinnings of metabolic medicine and the integration of laboratory findings with clinical practice, this classic textbook retains its focus on clinical relevance and is.
Biomarkers of Inborn Errors in Metabolism: Clinical Aspects and Laboratory Determination is structured around the new reality that laboratory testing and biomarkers are an integral part in the diagnosis and treatment of inherited metabolic diseases.
The book covers currently used biomarkers as well as markers that are in development. Disorders of lipid metabolism. Lipids are large, water-insoluble molecules that have a variety of biological functions, including storing energy and serving as components of cellular membranes and that line the small intestine absorb dietary lipids and process them into lipoprotein particles that enter the circulation via the lymphatic system for eventual uptake by the liver.
The correlated metabolites are primarily in the pathways involving amino acid, sugar, and purine metabolism, lipid metabolism and transport, and glycolysis. A number of metabolites in these pathways are also heritable, suggesting the possibility that genetic variations within these pathways may contribute to the heritability of hemolysis.
This model system is well suited to dissect genetic interactions and identify new players that link impairment of lipid metabolism to a dysfunctional heart. This will ultimately help design new therapeutic strategies to protect the heart against the deleterious effects of high caloric diets or genetic.
Several altered metabolites were identified, including l-asparagine, citric acid, l-isoleucine, and hypoxanthine. Furthermore, the pathway analysis of serum metabolomics demonstrated that the TCA cycle and fatty acid metabolism were disrupted in CIA rats.
Disorders in purine metabolism were observed from the results of fecal metabolomics analysis. Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism () Fenofibrate: a lipid lowering drug with uricosuric properties.
and Gout. In: Gresser U. (eds) Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism. Springer. Triacylglyceride (TG) accumulation in pancreatic β-cells is associated with impaired insulin secretion, which is called lipotoxicity.
To gain a better understanding of the pathophysiology of lipotoxicity, we generated three models of dysregulated fatty acid metabolism in β-cells. The overexpression of sterol regulatory element binding protein-1c induced lipogenic genes and TG accumulation.
Our studies provide novel insights into lipid biology in SCLC cells and comparisons with future analyses in other cancer types will identify unique aspects of lipid metabolism in SCLC cells. For example, SCLC cells have been observed to require lipid-raft mediated SRC-PI3K/AKT activation for sustained growth in.
Lipid metabolism in DHEA-exposed oocytes. Inhibition of the pentose phosphate pathway leads to decreased ribosephosphate and NADPH. Given that NADPH is used during multiple steps of the lipid synthesis process, we measured the effect of DHEA on lipid synthesis.
Metabolism is the physiological and biochemical mechanisms by which foodstuffs are taken in by the body and converted from one form to another to provide energy for all the activities of the body. Metabolism includes the methods our cells use to build multitudes of specific molecules that the body uses for its myriad activities.
Pathway enrichment analysis using Mummichog showed significant enrichment (plipid and amino acids metabolism: glycerophospholipid metabolism, glycosphingolipid metabolism, aspartate and asparagine metabolism, purine and pyrimidine metabolism, and xenobiotics metabolism (Fig 2D and S3 Table).